We are deriving a variety of human pluripotent stem cells for different purposes

Haploid human pluripotent stem cells contain just 23 chromosomes and are useful for genetic screening.

INSATG>ATA corrected

Stem cells derived by somatic cell nuclear transfer are patient matched, and can provide a source of autologous cells for cell replacement. We are interested in using this approach for the treatment of diabetes.

Somatic cell nuclear transfer involves the removal of the egg DNA (spindle), followed by the transfer of a the genome of a somatic cell.

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Presentations

Discussion on heritable genome editing at the Columbia Alumni Association, with Sam Sternberg and Frances Onyimba. April 22, 2021. Recording is here.

Press Links

On the consequences of Cas9 mediated gene editing in the germ line:

Wall Street Journal and

the New York Times.

http://content.time.com/time/specials/packages/article/0,28804,2101745_2102309_2102418,00.html

http://phys.org/news/2014-04-disease-specific-human-embryonic-stem-cell.html

http://www.nytimes.com/2014/06/29/magazine/the-brave-new-world-of-three-parent-ivf.html