Trip to Rockefeller Center in New York City
DNA damage in early embryo nuclei
it started as a public school, actually....
Trip to Rockefeller Center in New York City
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WHAT WE DO:
We study the earliest steps of human development from the zygote to an adult functional cell to learn fundamental principles about development and cell differentiation.
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Join us to figure out some important challenges:
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Disease Modeling and Cell Therapy for Diabetes. Understanding metabolic disorders using stem cells.
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Understanding genome stability and preventing abnormalities in early development.
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Understanding barriers to changes in cellular states in development, reprogramming, and differentiation
The Egli lab is located in New York City, United States.
Our most recent published work:
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NEW: Efficient base editing and development in human embryos without chromosomal alterations. Our new preprint shows that base editing avoids the chromosomal breaks and large deletions seen with Cas9, allowing normal development to the blastocyst stage and derivation of edited stem cell lines. Preprint on bioRxiv, and covered by CNN, NY Times, WSJ, Nature, STAT,...
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​Discover how embryos begin to organize their genome at the very beginning of life.
​PhD Student Shuangyi Xu and postdoctoral fellow Ning Wang discover that embryos establish a pattern of DNA replication in the first cell cycle, concordant with compartmentalization. This also shapes the stability and instability of specific genomic regions:
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Asymmetric Attrition at DSB sites in early mammalian development. Turocy, Jerabek et al. Nat Comms 2026
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility. Xu, Wang et al. Nat Comms 2024
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for more studies, see people profiles
All publications see here.