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We study the earliest steps of human development from the zygote to an adult functional cell to learn fundamental principles about development and cell differentiation.

Join us to figure out some important challenges:

  • Disease Modeling and Cell Therapy for Diabetes. Understanding metabolic disorders using stem cells.

  • Understanding genome stability and preventing abnormalities in early development. See why in Nature.

  • Physiological function of late replicating fragile sites. Read why here


The Egli lab is located in New York City, United States.


Our most recent published work:

BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.

Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D.Cell Rep. 2024 Mar 29;43(4):114006. doi: 10.1016/j.celrep.2024.114006. Online ahead of print.PMID: 38554279 

for more studies, see people profiles

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