Selected publications by area of research


Diabetes and Metabolism

Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. Journal of Clinical Investigation, Jan 2, 2015.

Shang, L., Hua, H., Foo, K., Martinez, H., Watanabe, K., Zimmer, M., Kahler, D., Freeby, M.,  Chung, W., LeDuc, C., Goland, R., Leibel, R., and Egli, D., Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes, Nov. 13, 2013.​​

Reprogramming, pluripotent stem cells

Sagi, I., Chia, G., Golan-Lev, T., Peretz, M., Weissbein, U., Sui, L., Sauer, M.V., Yanuka, O., Egli, D. and Benvenisty, N. Derivation and differentiation of haploid human embryonic stem cells (co-corresponding authors). Nature March16, 2016. 10.1038/nature17408.


Yamada, M., Johannesson, B., Sagi, I., Burnett, L.C., Kort, D.H., Prosser, R.W., Paull, D., Nestor, M.W., Freeby, M., Greenberg, E., Goland, R.S., Leibel, R.L., Solomon, S.L., Benvenisty, N., Sauer, M.V., and Egli, D. (2014), Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature, doi:10.1038/nature13287, Jun 26, 2014, 510(7506), pp. 533-6.

Egli, D., Rosains, J., Birkhoff, G., Eggan, K. Embryonic stem cells and cloned animals produced by chromosome transfer into mouse zygotes. Nature, 2007 Jun7; 447:79-85.

Noggle, S., Fung, H., Gore, A., Martinez, H., Crumm, C., Prosser, R., Oum, K., Paull, D., Druckenmiller, S., Freeby, M., Greenberg, E., Zhang, K., Goland, R., Sauer, M., Leibel, R., and Egli, D. Human oocytes reprogram somatic cells to a pluripotent state. Nature 2011, 478; 70-75.

Mitochondrial Replacement

Yamada M, Emmanuele V, Sanchez-Quintero MJ, Sun B, Lallos G, Paull D, Zimmer M, Pagett S, Prosser RW, Sauer MV, Hirano M, Egli D. Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes. Cell Stem Cell. 2016 Jun 2;18(6):749-54. doi: 10.1016/j.stem.2016.04.001. Epub 2016 May 19

Paull, D., Emmanuele, V., Hirano, M., Sauer, M. and Egli, D. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature, 2012, Dec.19, doi10.1038/nature11800.

Genetic stability:

Kort, D.H., Chia, G., Treff, N.R., Tanaka, A.J., Xing, T., Vensand, L.B., Micucci, S., Prosser, R., Lobo, R.A., Sauer, M.V. and Egli, D. Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy and developmental arrest.  Hum Reprod, Nov. 29, 2015. doi: 10.1093/humanrep/dev281